Inhaltsverzeichnis
This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about days for the tolerance to be reduced to half and weeks to be back at baseline . Modafinil may present a cross-tolerance with all benzhydryl nootropics, meaning that after the consumption of modafinil, all related eugeroic compounds such as armodafinil and adrafinil will display a reduced effect. Adderall and modafinil are central nervous system stimulant medications with similar mechanisms of action and practical applications, but different potentials for abuse. Adderall is considered to be a much more serious potential drug of abuse than modafinil. However, there are case studies that suggest that modafinil can be a potential drug of abuse, particularly when it is used in high amounts.
- MedTerms medical dictionary is the medical terminology for MedicineNet.com.
- Cyclizine increases and modafinil decreases sedation.
- Each month in his online column, Dr Andrade considers theoretical and practical ideas in clinical psychopharmacology with a view to update the knowledge and skills of medical practitioners who treat patients with psychiatric conditions.
- Cenobamate will increase the level or effect of modafinil by affecting hepatic enzyme CYP2C19 metabolism.
- Risk of acute hypertensive episode.
Like amphetamines, modafinil promotes wakefulness by stimulatIng the brain. The exact mechanism of action of modafinil is unknown. It may work by increasing the amount of dopamine in the brain by reducing the reuptake of dopamine into nerves. Modafinil was approved by the FDA in December 1998.
What Is This Drug Used For?
In summary, the bulk of research into modafinil’s wake-promoting mechanism has focused mostly on possible extracellular activities of modafinil. We propose that more work be done on examining potential intracellular mechanisms of modafinil and finding a point of convergence of modafinil’s stimulant and neuroprotective effects. It is likely that modafinil both enhances cellular metabolism and reduces free-radicals in neurons (Pierard et al 1995; Xiao et al 2004). Reduction in brain oxidation or an increase in cortical creatine could promote vigilance (Ikeda et al 2005; McMorris et al 2006), and each effect can increase neurotransmitter release by reducing inhibitory KATP-channel activity.
Sleep Quiz: Sleep Hygiene & Sleep Facts
Discuss with your doctor or pharmacist azithromycin if you should use additional reliable birth control methods while using this medication and for 1 month after stopping this medication. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well. For obstructive sleep apnea, take this medication by mouth with or without food as directed by your doctor, usually once daily in the morning. Continue your other treatment unless your doctor tells you to stop. For narcolepsy, take this medication by mouth with or without food as directed by your doctor, usually once daily in the morning.
Legal Risk
This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Call your doctor for medical advice about side effects. You may report side effects to FDA at FDA-1088 or at /medwatch. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects.